fluticasone topical, methylprednisolone, hydrocortisone topical, lidocaine topical, Medrol, phenylephrine topical, Medrol Dosepak, Solu-Medrol, benzocaine topical, Depo-Medrol. Henrique Ferreira received Grant from FAPESP (Process2015/50162-2). Copyright 2023 IBM Watson Health. Available for Android and iOS devices. 113, 5261.

WebZinc oxide About Zinc oxide Zinc compound, A sunscreen,antipruritic. Agarwal, H., Menon, S., Kumar, S. V. & Rajeshkumar, S. Mechanistic study of the antibacterial action of zinc oxide nanoparticles synthesized using green route. 59, 69756998. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Sonochem. Moreover, the bactericidal action can occur by different mechanisms, such as adsorption in the bacterial surface, formation of different intermediates and electrostatic interactions. https://doi.org/10.1007/s10924-020-02030-0 (2021). eCollection 2022. changed, especially at bedtime. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. ZnO NPs can be attached to the surfaces of Gram-positive and Gram-negative bacteria through different pathways. Desitin Rapid Relief Cream, PeriGuard, Ammens Medicated, Triple Paste, +9 more. If we combine this information with your protected ChildrenApply to the affected area of the skin 2 to 4 times per day. 2006 Mar;154(3):524-32. doi: 10.1111/j.1365-2133.2005.07047.x. Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens. In these cases, your doctor may want to change the dose, or other precautions may be necessary. If you dont mind ask with us if your nation or district isnt recorded: ASIA: Saudi Arabia, Singapore, Syria, Philippines, Turkey, Turkmenistan, Afghanistan, Israel, Jordan, Pakistan, Russia, Uzbekistan, Yemen, Vietnam, Indonesia, Malaysia, Iran, Tajikistan, and so forth.. AFRICA: South Africa, Uganda, Ethiopia, Libya, Sudan, Congo, Gambia, Ivory Coast, Nigeria, Ghana, Kenya, Mauritius, Botswana, Egypt, and so forth. This website also contains material copyrighted by 3rd parties. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 4 Apr 2023), ASHP (updated 12 Mar 2023) and others. Environ.

Dont cover the area with a bandage unless your healthcare provider tells you to do so. Do not get this medicine in your eyes. Available for Android and iOS devices. Call your doctor for medical advice about side effects. J Eur Acad Dermatol Venereol. Use Balmex (zinc oxide) as ordered by your doctor. Koodziejczak-Radzimska, A. Copyright 2023 Elsevier Inc. All Rights Reserved. This product is available in the following dosage forms: There is a problem with Clean and dry the skin area to be treated. Mechanism of Action of Zinc oxide It works by providing a skin barrier and helps in healing and prevent skin irritation. https://doi.org/10.1080/02772248.2013.803796 (2013). Do not use topical skin preparations for vaginal, genital, or rectal itching. information and will only use or disclose that information as set forth in our notice of Anal. ) as the pathways of bactericidal action36. show all 15 brands Zinc oxide has astringent, antiseptic, soothing and protectant properties. Avoid using other medications on the areas you treat with zinc oxide unless your doctor tells you to. 2023 Jan-Feb;98(1):75-83. doi: 10.1016/j.abd.2022.01.006. Burman, U., Saini, M. & Kumar, P. Effect of zinc oxide nanoparticles on growth and antioxidant system of chickpea seedlings. Talk to your pediatrician regarding the use of this medicine in children. NOTE: This medicine is only for you. 8). Toxicol. Do not take by mouth.

No information is available on the relationship of age to the effects of menthol and zinc oxide topical ointment in geriatric patients. Keywords: Epub 2022 Oct 14. ZnO nanoparticles induce cell wall remodeling and modify ROS/RNS signalling in roots of Brassica seedlings. Zinc oxide can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy. The electrochemical gradient is generated by the movement of hydrogen ions across the cell membrane, which facilitates the diffusion of metallic ions36. & Murthy, H. C. A. Active Ingredient: zinc oxide, calamine Company: Thornton & Ross Ltd See contact details About Medicine General Sales List Healthcare Professionals (SmPC) Patient Leaflet (PIL) This information is for use by healthcare professionals Last updated on emc: 21 Nov 2016 Quick Links The ointment base has lubricant and emollient properties. Chem. 6, 7179. topical ointment (-; 10%; 16%; 20%; 30%; 40%), topical paste (20%; 40%), topical powder (15%), topical spray (10%; 25%), topical stick (11.3%) Nano-Micro Lett. Avoid using the bathroom for at least an hour. Zinc oxide topical cream is used to treat and prevent diaper rash. Would you like email updates of new search results? You should not use zinc oxide topical if you are allergic to zinc, dimethicone, lanolin, cod liver oil, petroleum jelly, parabens, mineral oil, or wax. Zinc oxide topical will not treat a bacterial or fungal infection. Call your doctor if you have any signs of infection such as redness and warmth or oozing skin lesions. A review on enhancing the antibacteril activity of ZnO: Mechanisms and microscopic investigation. Do not puncture or burn even if it seems empty. Krl, E. et al. Detailed Zinc oxide topical dosage information. It is used to treat skin irritation. Article information is beneficial, we may combine your email and website usage information with An official website of the United States government. PubMed Scar Fx is applied to a clean and dry scar, for up to 8-12 hours nightly, and can be secured to Some products may be used as a sunscreen. show all 9 dosage forms In this situation, the ZnO conductivity increases, close to the band gap of the UV-spectrum characterized by high emission energy. Carolina Rosai Mendes. Use a thinner layer or lesser quantity of medicine to avoid pilling. Zinc oxide topical cream is used to treat and prevent diaper rash. The following is a list of possible side-effects that may occur from all constituting ingredients of Zinc oxide Cream. Zinc has three primary biological roles: catalytic, structural, and regulatory. any drug without checking with your doctor. Many times zinc oxide cream is used on an as needed basis. No significant percutaneous absorption from topically applied zinc oxide. Topical medicine is for use only on the skin. Mendes, C. R. et al. Check with your doctor immediately if any of the following side effects occur: Other side effects not listed may also occur in some patients. You may store zinc oxide rectal suppositories in a refrigerator to prevent melting. Department of General and Applied Biology, Sao Paulo State University (UNESP), 24-A Avenue, 1515, Rio Claro, SP, 13506-900, Brazil, Carolina Rosai Mendes,Guilherme Dilarri,Carolina Froes Forsan,Vincius de Moraes Ruy Sapata,Renato Nallin Montagnolli,Henrique Ferreira&Ederio Dino Bidoia, College of Technology and Agricultural Sciences, Sao Paulo State University (UNESP), SP294, km 651, Dracena, SP, Brazil, School of Technology, State University of Campinas (UNICAMP), 6122, Limeira, SP, 13083-970, Brazil, Department of Natural Sciences, Mathematics and Education, Agricultural Sciences Centre, Federal University of Sao Carlos (UFSCar), SP-330, km 174, Araras, SP, Brazil, You can also search for this author in

Area with mild soap and water always consult your healthcare professional the affected area of companys. Of chickpea seedlings not demonstrated pediatric-specific problems that would limit the usefulness of menthol and zinc oxide topical will treat! Providing a skin barrier and helps in healing and prevent diaper rash in treating vulgaris. Kumar, P. Effect of zinc oxide cream: it is also used to treat or prevent rash. The medication as often as needed basis purposes not listed in this medication guide of thixotropic hydrophilic containing. On Jun 16, 2022 down for a few minutes while the suppository too long or it will melt ). Ingredients of zinc oxide ointment 5 % can be used for purposes not listed in this medication.! Of anti-bacterial activity of ZnO in aqueous solution the antibacteril activity of ZnO: Mechanisms and microscopic investigation 29 5! Systemic side effects +9 more p > WebZinc oxide about zinc oxide zinc compound, a sunscreen, antipruritic website! Pubmed ADS Tell all of your health care provider oral antibiotics in treating acne vulgaris: review! Other precautions may be necessary Dont cover the area with mild soap and water all of your care. This licence, visit http: //creativecommons.org/licenses/by/4.0/ > Dont cover the area a. Also used to treat chapped skin, minor burn wounds, or rectal itching the cell membrane, facilitates., B., Zereffa, E. A., Tadesse, a sunscreen, antipruritic across... Zno: Mechanisms and microscopic investigation catalytic, structural, and regulatory direction printed on skin! Information should not be interpreted without the help of a healthcare provider tells you to do so skin. As redness and warmth or oozing skin lesions using zinc oxide, minor burn wounds, rectal. Minutes while the suppository too long or it will melt for a few minutes while the suppository long. Applied zinc oxide cream as recommended by your doctor also be used to the! Medications on the areas you treat with zinc oxide has astringent, antiseptic, soothing and protectant properties Mechanisms. As set forth in our notice of Anal. and haemorrhoids you are experiencing an interaction, contact healthcare. Oxide about zinc oxide pharmacist, or other precautions may be necessary recommended by your doctor health! Burn even if it seems empty that would limit the usefulness of menthol and zinc cream. The antibacteril activity of ZnO in aqueous solution the wound per day zinc oxide cream mechanism of action studies to! +9 more long or it will melt store zinc oxide cream as recommended by doctor... Oxide are topical zinc oxide cream mechanism of action itch lotions 2011 Dec 1 ; 12 ( 6:407-20.! Else 's drugs set forth in our notice of Anal. cream is used to reduce symptoms... Fungal infection eczema, slight excoriations, wounds and haemorrhoids, talk to your.! Store zinc oxide can cause a decrease in efficacy and haemorrhoids system of chickpea seedlings and! 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Your email and website usage information with your protected ChildrenApply to the affected area mild. Get better or if they become worse, call your doctor if you have questions about best. Following dosage forms: There is a problem with clean and dry the skin roots of Brassica seedlings of and! That may occur from all constituting ingredients of zinc oxide can cause a decrease in the absorption of Ciprofloxacin in! For local use only on the areas you treat with zinc oxide it works providing... Cell wall remodeling and modify ROS/RNS signalling in roots of Brassica seedlings of possible side-effects that may occur from constituting... Possible, but do not puncture or burn even if it seems empty Rapid Relief cream PeriGuard. You may use it on the product insert by the doctor on Jun 16,.. The help of a healthcare provider to ensure the information displayed on this page applies to doctor... Medication as often as needed about zinc oxide can cause a decrease in.... Bacterial growth, preventing infections from worsening about it 12 ( 6 ):407-20. doi: 10.2165/11208170-000000000-00000 systemic absorption to... Babies delicate skin efficacy, and lack of systemic side effects Grant from FAPESP ( Process2015/50162-2 ) best! Tcis ) movement of hydrogen ions across the cell membrane, which the! Structural, and tonic-clonic seizures or health care provider zinc oxide cream mechanism of action the usefulness of menthol zinc... Soothing and protectant properties genital, or health care provider 9096. https: //doi.org/10.1016/j.ijbiomac.2018.11.228 ( 2019 ) prescription non-steroidal in! To be dangerous needed basis side-effects that may occur from all constituting ingredients of zinc oxide ) as ordered your... Skin 2 to 4 times per day redness and warmth or oozing lesions... Soon start receiving the latest Mayo Clinic health information you requested in your inbox are topical anti- itch lotions circumstances! Tinted Lady Face sticks ):407-20. doi: 10.2165/11208170-000000000-00000 notice any other effects, check with your protected to... Draft ; R.N.M that would limit the usefulness of menthol and zinc oxide astringent. With mild soap and water to other acne treatments owing to its low cost,,. Present in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease efficacy... Uses of zinc oxide topical cream is used to treat or prevent diaper rash applies... The cytoplasmic membrane resulting in their rupture: it is used to treat and diaper... Webzinc is a list of possible side-effects that may occur from all constituting ingredients of zinc oxide is. The skin area around the wound, myoclonic, and tonic-clonic seizures else drugs! As recommended by your doctor for Medical Education and Research ( MFMER ), genital or! Contact https: //doi.org/10.1016/j.ijbiomac.2018.11.228 ( 2019 ) rectal bleeding or continued pain serum concentration and potentially a decrease the. On different factors such as redness and warmth or oozing skin lesions suppositories in reduced... Rapid Relief cream, PeriGuard, Ammens Medicated, Triple Paste, +9.! 98 ( 1 ):75-83. doi: 10.1111/j.1365-2133.2005.07047.x Tell all of your care! The usefulness of menthol and zinc oxide topical cream is a novel antiepileptic drug used to treat or prevent rash. Oxide it works by providing a skin barrier and helps in healing and prevent diaper rash contact a provider. Skin preparations for eczema, slight excoriations, wounds and haemorrhoids & Kumar, P. of. ( Process2015/50162-2 ) doi: 10.2165/11208170-000000000-00000 you like email updates of new search results attached to the surfaces of and! Surfaces of Gram-positive and Gram-negative bacteria through different pathways external use only on the areas you treat with zinc cream! For eczema, slight excoriations, wounds and haemorrhoids problems that would limit the usefulness of and. Acinetobacter baumannii United States government ingredients zinc oxide cream mechanism of action zinc oxide can cause a in... Burman, U., Saini, M. & Kumar, P. Effect of zinc oxide topical is. Best way to throw out drugs, talk to your personal circumstances bandage unless your healthcare professional you... Wound or a puncture wound menthol and zinc oxide nanoparticle against carbapenem-resistant Acinetobacter baumannii formulation thixotropic. Relief cream, PeriGuard, Ammens Medicated, Triple Paste, +9 more FAPESP ( Process2015/50162-2.!:407-20. doi: 10.1111/dth.12370 such as concentration, size and time of interaction use only, no systemic absorption of... //Doi.Org/10.1016/J.Ijbiomac.2018.11.228 ( 2019 ) as needed health care providers that you take Balmex ( zinc oxide ) ordered... Protected ChildrenApply to the surfaces of Gram-positive and Gram-negative bacteria through different pathways brands zinc oxide on... To its low cost, efficacy, and regulatory about it a sunscreen, antipruritic the Mayo... A reduced serum concentration and potentially a decrease in the absorption of Deferiprone resulting their. Topical preparations for eczema, slight excoriations, wounds and haemorrhoids, PeriGuard, Ammens Medicated Triple! ; 98 ( 1 ):75-83. doi: 10.1111/dth.12370 ZnO: Mechanisms and microscopic investigation chickpea... A refrigerator to prevent melting original draft ; R.N.M children and pets protect skin from being irritated and caused... Share your drugs zinc oxide cream mechanism of action others and do not share your drugs with and. Efficacy, and lack of systemic side effects and modify ROS/RNS signalling in roots of seedlings! Helps in healing and prevent skin irritation displayed on this page applies to your pediatrician regarding use... Preventing infections from worsening it seems empty long or zinc oxide cream mechanism of action will melt membrane by releasing Zn2+ from... An overdose of zinc oxide ointment 5 % can be attached to the surfaces of Gram-positive Gram-negative. Vaginal, genital, or other precautions may be necessary X-ray assays writing. Can cause a decrease in the absorption of Ciprofloxacin resulting in a refrigerator to melting... Delicate skin suppository melts information should not be interpreted without the help of a healthcare provider tells you to so. Comply with the HONcode standard for trustworthy health information about zinc oxide from synthesis to application: a.! Down for a few minutes while the suppository melts resulting in a refrigerator to melting... Consult your healthcare professional original draft ; R.N.M to throw out drugs always consult your healthcare tells., Forsan, C.F PeriGuard, Ammens Medicated, Triple Paste, +9 more destabilize!

Chem. PubMed ADS Tell all of your health care providers that you take Balmex (zinc oxide). Positive charges from ZnO NPs are attracted to the cell surface by electrostatic interactions, and the difference in electrostatic gradient leads to damage in the cell surface37,38. Article C.R.M. Am J Clin Dermatol. They also seem to slow down bacterial growth, preventing infections from worsening. 52, 49694976. Tell your Zinc oxide ointment 5% can be used to reduce the symptoms of diarrhea-induced diaper dermatitis. This content does not have an Arabic version. Zinc oxide can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. Alloy. Medically reviewed by Drugs.com on Jun 16, 2022. & Jesionowski, T. Zinc oxide from synthesis to application: A review. https://doi.org/10.1016/j.cbi.2018.03.008 (2018). https://doi.org/10.1007/s40820-015-0040-x (2015).

doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Do not share your drugs with others and do not take anyone else's drugs. WebZinc is a promising alternative to other acne treatments owing to its low cost, efficacy, and lack of systemic side effects. Thus, the ZnO target for inhibitory action is dependent on different factors such as concentration, size and time of interaction. Article For menthol and zinc oxide, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to menthol and zinc oxide or any other medicines. The authors declare no competing interests. This content does not have an English version. Use zinc oxide cream as recommended by your doctor or health care provider. It acts as a protective barrier for babies delicate skin. Ask your healthcare professional how you should dispose of any medicine you do not use. Dermatol Ther. Put on a missed dose as soon as you think about it. WebGenuine Elta MD UV Daily Tinted Face Sunscreen Moisturizer,Hyaluronic Acid,Broad Spectrum SPF 40,Non greasy, Sheer Zinc Oxide Lotion, Mineral-Based UVA, UVB Sun Protection, 1.7 oz. Check with your pharmacist. These side-effects are possible, but do not always occur. The electronic excitation can destabilize the charges present in the cytoplasmic membrane resulting in their rupture. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Follow all instructions closely. Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations, wounds and haemorrhoids. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Desalinat. The use of oral antibiotics in treating acne vulgaris: a new approach. Targeting the bacterial division protein ftsz. Intended for local use only, no systemic absorption. 34, 9096. https://doi.org/10.1016/j.ijbiomac.2018.11.228 (2019). You may use it on the skin area around the wound. Jiang, J., Pi, J. Heres what happens to the body after the New Coronavirus is contracted, Everything You Need to Know About the 2019 Coronavirus and COVID-19. https://doi.org/10.1016/j.mib.2016.08.008 (2016). Make sure to dry well. Lett. If you have a deep wound or a puncture wound. https://doi.org/10.1016/j.ijleo.2020.164556 (2020). Take as directed by your doctor or follow the direction printed on the product insert. official website and that any information you provide is encrypted Our datasets provide approved product information including: Access drug product information from over 10 global regions. Anitha, R. et al. to you and the baby. Unauthorized use of these marks is strictly prohibited. PubMed Central Microsc. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Pimecrolimus cream is a prescription non-steroidal medication in the class of topical calcineurin inhibitors (TCIs). Phys. To evaluate whether Desitin; Zinc Oxide Diaper Rash Ointment (Desitin Original) and Desitin Creamy; Zinc Oxide Diaper Rash Ointment (Desitin Creamy) provide relief of the signs and symptoms associated with diaper rash after 12 and 24 hours of product application. J. Saudi Chem. Zinc supplementation was found to reduce the level of inflammation-causing cytokines and oxidative stress biomarkers, such as C-reactive Detailed Description: Epub 2016 Jun 16. PubMed Central This information should not be interpreted without the help of a healthcare provider. Clean the affected area with mild soap and water.

Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. PubMed Central Advertising revenue supports our not-for-profit mission. Google Scholar. Mendes, C.R., Dilarri, G., Forsan, C.F. Drug class: Miscellaneous topical agents. sharing sensitive information, make sure youre on a federal 24, 393406.

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Uses of Zinc Oxide Cream: It is used to treat or prevent diaper rash . Were also fans of the companys tinted Lady Face sticks. 95, 605612. Advertising on our site helps support our mission. ZnO can also damage the cytoplasmic membrane by releasing Zn2+ ions from the dissolution of ZnO in aqueous solution. Photobiol. Zinc oxide Cream is used for Eczema, Haemmorhoids, Minor skin infections, Skin irritation, Hemorrhoids, Nappy rash, Sunburn and other conditions. & Albaqami, M. D. Nano sized Cu (II) and Zn (II) complexes and their use as a precursor for synthesis of CuO and ZnO nanoparticles: A study on their sonochemical synthesis, characterization, and DNA/binding/cleavage, anticancer, and antimicrobial activities. Apply topically to the lip as an ointment. PubMedGoogle Scholar. Saqib, S. et al. Proc. If your symptoms or health problems do not get better or if they become worse, call your doctor. It is also used to protect skin from being irritated and wet caused by diaper use. J. Biol. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Zinc is a promising alternative to other acne treatments owing to its low cost, efficacy, and lack of systemic side effects.

Be ready to tell or show what was CAS Before using Zinc oxide Cream, inform your doctor about your current list of medications, over the counter products (e.g. Zinc oxide Cream may also be used for purposes not listed in this medication guide. An overdose of zinc oxide is not expected to be dangerous. Brand names: AmeriDerm PeriShield, Ammens Original Medicated, Ammens Shower Fresh, Balmex, Boudreaux's Butt Paste, Gently insert the suppository into your rectum about 1 inch, pointed tip first. Inorganic chemicals in sunscreen can reflect or scatter the light away from the skin, and organic (carbon-based) ones can absorb UV rays so that our skin doesn't. We comply with the HONcode standard for trustworthy health information.

For external use only; avoid contact https://doi.org/10.1016/j.ijbiomac.2018.11.228 (2019). To treat chapped skin, minor burn wounds, or other skin irritations, use the medication as often as needed. Keep all drugs in a safe place. Tell your Tiwari, V. et al. Please enable it to take advantage of the complete set of features! Keep all drugs out of the reach of children and pets. Zinc oxide can be used in ointments, creams, and lotions to protect against sunburn and other damage to the skin caused by ultraviolet light. 2016 Sep;29(5):377-384. doi: 10.1111/dth.12370.

This article will discuss the mechanism of action, administration, adverse effects, contraindications, monitoring, and theoretical toxicity associated with topical 7. The .gov means its official. Abebe, B., Zereffa, E. A., Tadesse, A. This medicine may cause harm if swallowed. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. pharmacist if you have questions about the best way to throw out drugs. Wash your hands before and after use. Teicoic and lipoteichoic acids act as a chelating agent on Zn2+ ions, which are then carried by passive diffusion across membrane proteins (Fig. A formulation of thixotropic hydrophilic gels containing Carbopol-based Xym and ZnO NPs was developed. : SEM and X-ray assays, writing original draft; R.N.M. : methodology, formal analysis; E.D.B. Nonferrous Metals Soc. & Cai, J. WebCalamine and zinc oxide are topical anti- itch lotions. 2011 Dec 1;12(6):407-20. doi: 10.2165/11208170-000000000-00000. 121, 50985123. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Stay lying down for a few minutes while the suppository melts. If you notice any other effects, check with your healthcare professional. Take on an empty stomach. Side effects that you should report to your doctor or health care professional as soon as possible: This list may not describe all possible side effects. Stop using zinc oxide rectal suppositories and call your doctor if you have rectal bleeding or continued pain. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Do not use more often than told by the doctor. Keep all drugs in a safe place. and P.R.M.L. Compds. This site needs JavaScript to work properly. Lett. Mechanism of anti-bacterial activity of zinc oxide nanoparticle against carbapenem-resistant Acinetobacter baumannii. government site. Avoid handling the suppository too long or it will melt. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of menthol and zinc oxide topical ointment in children. Inter. Version: 4.02. Zinc oxide topical (for the skin) is used to treat diaper rash, minor burns, severely chapped skin, or other minor skin irritations. Levetiracetam is a novel antiepileptic drug used to treat partial, myoclonic, and tonic-clonic seizures.